Assistant Professor of Medical Statistics at the London School of Hygiene and Tropical Medicine. John's main field of interest is the design and analysis of clinical trials, particularly those in cardiovascular disease.
Affiliations
Department of Medical Statistics
Faculty of Epidemiology and Population Health
Teaching
John co-organises modules on Clinical Trials and Statistical Inference on the Medical Statistics MSc.
He also teaches statistical methods relevant to cardiology trials on short courses aimed at Cardiologists.
He also teaches statistical methods relevant to cardiology trials on short courses aimed at Cardiologists.
Research
John has a particular interest in demystifying statistical methods and assessing their value and best use in trials in cardiology. Major current topics of research include: the win ratio approach to a hierarchical composite of outcomes with clinical priorities, the value of repeat-event versus time-to-first event analyses, the use of covariate adjustment in clinical trials, and how best to handle competing risks.
Outside of methodological work, he provides expert statistical advice on a number of trials in cardiology and is the statistical member of several trial data monitoring committees.
Outside of methodological work, he provides expert statistical advice on a number of trials in cardiology and is the statistical member of several trial data monitoring committees.
Selected Publications
Nonproportional Hazards for Time-to-Event Outcomes in Clinical Trials: JACC Review Topic of the Week.
2019
Journal of the American College of Cardiology
Comparison of Propensity Score Methods and Covariate Adjustment: Evaluation in 4 Cardiovascular Studies.
2017
Journal of the American College of Cardiology
Comparative prognostic importance of measures of left atrial structure and function in non-ischaemic dilated cardiomyopathy.
2024
European heart journal. Cardiovascular Imaging
Quantifying the benefit-risk trade-off for individual patients in a clinical trial: principles and antithrombotic case study.
2024
Journal of thrombosis and haemostasis : JTH
Sex Differences in the Clinical Presentation and Natural History of Dilated Cardiomyopathy.
2023
JACC. Heart failure
Phenotype, outcomes and natural history of early-stage non-ischaemic cardiomyopathy.
2023
European journal of heart failure
Recurrent Events in Cardiovascular Trials: JACC State-of-the-Art Review.
2023
Journal of the American College of Cardiology