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Mr Luke Vale

Professor of Health Economics

United Kingdom

I am a researcher with an international reputation in economic evaluation and health technology assessment and have contributed significantly to the growth in the use of systematic reviews and economic modelling in this field. This expertise is built on nearly 30 years of health economics experience. I am currently a Professor of Health Economics which I joined in 2023. I am a member and health economics lead for the NICE funded Newcastle External Assessment Centre and lead health economist for the NIHR Behavioural Science Policy Research Unit. I am chair of the Executive of the NIHR research Support Service for the North East and North Cumbria,

Prior to joining LSHTM I led the Health Economics Group at Newcastle University. I was also Director of the NIHR funded Newcastle Technology Assessment Review Centre and collaborator and theme lead for the Enabling Methodologies Theme of the NIHR Applied Research Collaboration and collaborator and lead health economist on other NIHR infrastructure including the NIHR Newcastle In Vitro Diagnostics Co-operative, Patient Safety Research Collaboration and the Blood and Transplant research Unit .

Until 2023 I was co-ordinating editor of the NIHR funded Cochrane Incontinence Review Group and following reorganisation of Cochrane I remain as a sign-off editor. I was also Chair from 2010 to 2020 of the joint economic methods group of the international Cochrane and Campbell Collaborations (http://methods.cochrane.org/economics/) which develops the methods and conducts systematic reviews of interventions in health care and other policy areas; I am still actively developing methodology in this area.

I have considerable managerial and supervisory experience including most recently as the Deputy Director of the Institute of Health & Society at Newcastle University (until 2019). I also have a proven record in attracting research funds, completing projects to a high standard and in a timely fashion. I have extensive links with policy makers and researchers throughout the UK and internationally and was economic advisor the recent Topol review on digital medicine. The total value of competitive peer reviewed funding I have been awarded is in excess £165 million including a substantial number as Principal Investigator. In addition, I have a strong publication record with well over 400 papers in peer-reviewed journals, 4 books, 15 book chapters and over 100 other significant reports.

Affiliations

Department of Health Services Research and Policy
Faculty of Public Health and Policy

Teaching

My main areas of teaching focus on the methods and application of economic evaluation in health care. This includes development of short courses on aspects of economic evaluation and health technology assessment for different groups nationally and internationally.

Research

Key research interests are:

Economic evaluation as part of randomised controlled trials and Health Technology Assessments for national and international agencies

Use of economic evaluation techniques in the design of complex interventions and health technologies

Development of methods for the incorporation of discrete choice experiments and willingness to pay estimates into economic evaluation

Identification and exploration of methods to improve the efficiency of economic evaluation research.
Research Area
Health economics
Clinical trials
Systematic reviews
Economic evaluation

Selected Publications

Longitudinal health-related quality of life in people with thoracic aortic aneurysms.
SHARPLES, LD; Anagnostopoulou, V; Pouncey, AL; Freeman, C; McCarthy, A; Gray, J; McMeekin, P; Sastry, P; VALE, L; Bicknell, C; Large, SR;
2024
The British journal of surgery
Polyp detection with colonoscopy assisted by the GI Genius artificial intelligence endoscopy module compared with standard colonoscopy in routine colonoscopy practice (COLO-DETECT): a multicentre, open-label, parallel-arm, pragmatic randomised controlled trial.
Seager, A; Sharp, L; Neilson, LJ; Brand, A; Hampton, JS; Lee, TJ W; Evans, R; VALE, L; Whelpton, J; Bestwick, N; Rees, CJ; COLO-DETECT trial team,;
2024
The lancet. Gastroenterology & hepatology
Development and pilot implementation of a novel protocol to assess capacity and readiness of health systems to adopt HPV detection-based cervical cancer screening in Europe.
Mensah, K; Mosquera, I; Tisler, A; Uusküla, A; Firmino-Machado, J; Lunet, N; Nicula, F; Tăut, D; Baban, A; Basu, P; CBIG-SCREEN Consortium,;
2024
Health research policy and systems
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD).
Vacca, M; Kamzolas, I; Harder, LM; Oakley, F; Trautwein, C; Hatting, M; Ross, T; Bernardo, B; Oldenburger, A; Hjuler, ST; Ksiazek, I; Lindén, D; Schuppan, D; Rodriguez-Cuenca, S; Tonini, MM; Castañeda, TR; Kannt, A; Rodrigues, CM P; Cockell, S; Govaere, O; Daly, AK; Allison, M; Honnens de Lichtenberg, K; Kim, YO; Lindblom, A; ... Vidal-Puig, A.
2024
Nature metabolism
NICE Approaches to Expert Opinion Evidence in Highly Specialised Technologies: Time to Change? Evidence Assessment Group Perspective.
Moradi, N; O'Connor, N; Thomson, KH; Shabaninejad, H; Sotire, T; Still, M; Fernandez-Garcia, C; Wallace, SA; Williams, O; VALE, L; Sagoo, GS;
2024
PharmacoEconomics
Feasibility and acceptability of autism adapted safety plans: an external pilot randomised controlled trial.
Rodgers, J; Cassidy, S; Pelton, M; Goodwin, J; Wagnild, J; Bhattarai, N; Gordon, I; Wilson, C; Heslop, P; Ogundimu, E; O'Connor, RC; Ramsay, SE; Townsend, E; VALE, L;
2024
EClinicalMedicine
Study protocol: optical coherence tomography angiography for the detection of neovascular age-related macular degeneration: a comprehensive multicentre diagnostic accuracy study in the UK-the ATHENA study.
Niestrata, M; Deeks, JJ; Takwoingi, Y; Sivaprasad, S; Patel, PJ; Keane, PA; Kernohan, A; VALE, L; Denniston, AK; Gale, R; Khan, AR; McKinnon, W; Agarwal, R; De Salvo, G; Minos, E; Barbeiro, P; Chakravarthy, U; Waheed, NK; Madhusudhan, S; Peto, T; Balaskas, K;
2024
BMJ open
Extracorporeal photopheresis (ECP) in the treatment of chronic lung allograft dysfunction (CLAD): a prospective, multicentre, open-label, randomised controlled trial studying the addition of ECP to standard care in the treatment of bilateral lung transplant patients with CLAD (E-CLAD UK).
Fisher, AJ; White, M; Goudie, N; Kershaw, A; Phillipson, J; Bardgett, M; Lally, J; Bevin-Nicholls, A; Chadwick, T; Bryant, A; Russell, S; Smith, H; Frisby, L; Errington, R; Carby, M; Thompson, R; Santhanakrishnan, K; Parmar, J; Lordan, JL; VALE, L; Hancock, H; Exley, C; Gennery, AR; Wason, JM;
2024
BMJ open respiratory research
Health-related quality of life in non-alcoholic fatty liver disease: A cross-cultural study between Spain and the United Kingdom.
Funuyet-Salas, J; Martín-Rodríguez, A; Pérez-San-Gregorio, MÁ; VALE, L; Robinson, T; Anstee, QM; Romero-Gómez, M;
2024
PloS one
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