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Dr Christian Bottomley

Associate Professor

United Kingdom

Jump to: Affiliations Teaching Research Publications
I joined the International Statistics and Epidemiology Group at LSHTM in 2008. Prior to joining LSHTM, I completed a PhD in mathematical biology at University College London (UCL) and worked as a medical statistician in the Department of Primary Care and Population Sciences, also at UCL.

Affiliations
Department of Infectious Disease Epidemiology and International Health
Faculty of Epidemiology and Population Health

Centres

Centre for Data and Statistical Science for Health
Centre for Evaluation
TB Centre
Antimicrobial Resistance Centre

Teaching
I am a course organiser for the module Design and Analysis of Epidemiological Studies, and also a tutor on the Epidemiology MSc and Clinical Trials MSc.

Research
I am statistician and infectious disease epidemiologist. My research centres around the evaluation of vaccines and other public health interventions aimed at reducing the burden of infectious disease among children in low-and-middle-income countries. I am also interested in the development of statistical methods, particularly around the analysis of time series data for evaluating population-level interventions.

I collaborate with researchers at various institutions, including the MRC Gambia, the KEMRI-Wellcome Trust Research Programme in Kenya, and more recently, the Biomedical Research and Training Institute (BRTI) in Zimbabwe.

Recently completed studies for which I was the principal statistician include:

• PregnAnZI-2: A trial evaluating the effectiveness of azithromycin, administered during labour, for preventing sepsis in newborns in The Gambia
• A trial of fractional doses of pneumococcal vaccines in Kenya

Ongoing studies for which I am the principal statistician include:

• IMPRESS: a cluster-randomised trial of a hospital management intervention in Malawi
• FIEBRE: a multi-country study investigating the causes of fever in children and adults
• SAVIS: a phase 1 trial of a vaccine against non-typhoidal Salmonella
• An evaluation of RajPusht - a complex intervention centred around a cash transfer programme for pregnant women in Rajasthan, India

Selected Publications
Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death: A Randomized Clinical Trial.
ROCA, A; CAMARA, B; Bognini, JD; Nakakana, UN; Somé, AM; Beloum, N; Rouamba, T; Sillah, F; Danso, M; Jones, JC; Graves, S; Jagne, I; Getanda, P; DARBOE, S; Tahita, MC; Ndure, E; Franck, HS; Edmond, SY; Dondeh, BL; Nassa, WG J; Garba, Z; BOJANG, A; Njie, Y; BOTTOMLEY, C; Tinto, H; ... PregnAnZI-2 Working Group,
2023
JAMA
In praise of Prais-Winsten: An evaluation of methods used to account for autocorrelation in interrupted time series.
BOTTOMLEY, C; OOKO, M; GASPARRINI, A; KEOGH, RH;
2023
Statistics in medicine
Quantifying previous SARS-CoV-2 infection through mixture modelling of antibody levels.
BOTTOMLEY, C; OTIENDE, M; Uyoga, S; GALLAGHER, K; Kagucia, EW; Etyang, AO; Mugo, D; Gitonga, J; Karanja, H; Nyagwange, J; ADETIFA, IM O; AGWEYU, A; Nokes, DJ; Warimwe, GM; SCOTT, JA G;
2021
Nature communications
Analysing Interrupted Time Series with a Control
BOTTOMLEY, C; SCOTT, JA G; Isham, V;
2019
Epidemiologic Methods
Effect of 10-valent pneumococcal conjugate vaccine on the incidence of radiologically-confirmed pneumonia and clinically-defined pneumonia in Kenyan children: an interrupted time-series analysis.
Silaba, M; OOKO, M; BOTTOMLEY, C; Sande, J; Benamore, R; Park, K; Ignas, J; Maitland, K; Mturi, N; Makumi, A; OTIENDE, M; Kagwanja, S; Safari, S; Ochola, V; Bwanaali, T; Bauni, E; Gleeson, F; Deloria Knoll, M; ADETIFA, I; Marsh, K; Williams, TN; Kamau, T; Sharif, S; Levine, OS; Hammitt, LL; ... SCOTT, JA G.
2019
The Lancet Global Health
Persistence of Nasopharyngeal Pneumococcal Vaccine Serotypes and Increase of Nonvaccine Serotypes Among Vaccinated Infants and Their Mothers 5 Years After Introduction of Pneumococcal Conjugate Vaccine 13 in The Gambia.
USUF, E; BOTTOMLEY, C; Bojang, E; Cox, I; BOJANG, A; Gladstone, R; KAMPMANN, B; Hill, PC; ROCA, A;
2018
Clinical infectious diseases
Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea.
MARKS, M; Mitjà, O; BOTTOMLEY, C; Kwakye, C; Houinei, W; Bauri, M; Adwere, P; Abdulai, AA; Dua, F; Boateng, L; Wangi, J; Ohene, S-A; Wangnapi, R; Simpson, SV; Miag, H; Addo, KK; Basing, LA; Danavall, D; Chi, KH; Pillay, A; Ballard, R; Solomon, AW; Chen, CY; Bieb, SV; Adu-Sarkodie, Y; ... Study team,
2018
The Lancet Global health
Housing Improvements and Malaria Risk in Sub-Saharan Africa: A Multi-Country Analysis of Survey Data.
TUSTING, LS; BOTTOMLEY, C; Gibson, H; KLEINSCHMIDT, I; Tatem, AJ; Lindsay, SW; Gething, PW;
2017
PLoS medicine
Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings.
BOTTOMLEY, C; Isham, V; Vivas-Martínez, S; Kuesel, AC; Attah, SK; Opoku, NO; Lustigman, S; Walker, M; Basáñez, M-G;
2016
Parasites & vectors
Oral azithromycin given during labour decreases bacterial carriage in the mothers and their offspring: a double-blind randomized trial.
ROCA, A; Oluwalana, C; BOJANG, A; CAMARA, B; KAMPMANN, B; BAILEY, R; Demba, A; BOTTOMLEY, C; D'ALESSANDRO, U;
2016
Clinical microbiology and infection
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Christian Bottomley

Contact

United Kingdom