London School of Hygiene & Tropical Medicine

In May 2020, England introduced a "soft" opt-out system for organ donation, following the earlier adoption of similar legislation in Wales (2015) and later Scotland (2021). The goal was to increase organ availability by presuming most adults to be willing donors unless they explicitly opted out. However, several years on, the anticipated improvements in organ donation rates have not materialised, and the implementation of the law has been shown to be more complicated than proponents had expected. What we did

Look deep into the structure of any cell or organism with a defined nucleus (eukaryote), and you are likely to find septins.Septins have been identified in nearly all eukaryotes, including humans. They are components of the cytoskeleton, a network of protein filaments that helps eukaryotic cells hold their shape and carry out essential functions.Septins were originally discovered by Nobel Laureate Leland Hartwell in 1971 as being essential for cell division in budding yeast.

Each year, an estimated 7.7 million deaths are caused by bacterial infections, globally. Out of these deaths, about 1.27 million are attributable to bacteria which have developed resistance to antibiotics. What is antibiotic resistance and what does it mean for us?

What’s the issue?Across many types of trials, the recruitment and retention of women is a challenge. In cardiovascular trials, approximately a third of participants are women.Why is there gender inequity in clinical trials?It’s often extremely challenging to recruit people to take part in clinical trials under any circumstances, so the focus has been on recruiting sufficient numbers rather than the ratio of men and women.