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Ms Katherine Gallagher

Associate Professor

United Kingdom

I am an epidemiologist trained in infectious disease epidemiology and vaccine research with experience of pre-licensure, post-licensure vaccine trials and post-introduction surveillance and evaluation projects.

My PhD research documented best practice in the introduction of Human Papillomavirus (HPV) vaccine delivery in 46 low- and middle-income countries and included a post-introduction evaluation study in Tanzania. During this time, I was based at the Mwanza Intervention Trials Unit for 2 years and aided the rapid set up of a Phase 1 Ebola Vaccine trial during the West African epidemic. My first post-doc position was as a london-based coordinator of the larger EBOVAC project at LSHTM, which included two different phase 2 vaccine trials in Sierra Leone of the two-dose Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen.

Since July 2018, I have been based at the KEMRI-Wellcome Trust Research Programme in Kenya leading a phase 4 trial assessing whether fractional doses of Pneumococcal Conjugate Vaccines (PCV) elicit non-inferior immunogenicity and effects on carriage as full doses. During the COVID-19 pandemic I led some of the serosurveillance for SARS-CoV-2 in Kenya and contributed to a household study of SARS-CoV-2 transmission. In collaboration with partners at the UVRI/MRC & LSHTM unit in Uganda, COMAHS in Sierra Leone and INRB in DRC, we obtained funding to conduct a mixed-methods evaluation of how the COVID-19 pandemic affected utilisation and provision of childhood vaccinations and other primary healthcare services in the three countries and we conducted longitudinal serosurveillance for SARS-CoV-2 among healthcare workers.

I currently supervise two PhD students who are assessing the relationship between PCV coverage and carriage, and the relationship between carriage and invasive pneumococcal disease in Ethiopia and DRC. I continue to be interested in improving our understanding of transmission of infectious diseases and our measurement of host susceptibility , in order to develop and use vaccines more effectively to control transmission and disease.

Affiliations

Department of Infectious Disease Epidemiology and International Health
Faculty of Epidemiology and Population Health

Centres

Centre for Epidemic Preparedness and Response

Teaching

I am a Fellow of the Advance Higher Education Academy (FHEA, Advance HE UK). I am a module co-organiser for the LSHTM Distance Learning MSc module: Epidemiological Study Design. I tutor on the LSHTM Distance Learning Epidemiology and Control of Communicable Disease Module. I lecture and tutor on the face-to-face MSc module ‘Design and Analysis of Epidemiological Studies’ and the short course: Epidemiological evaluation of vaccines: efficacy, safety and policy.

Research

High-quality epidemiological research to inform vaccine policy
Research Area
Adolescent health
Bacteria
Child health
Clinical trials
Evaluation
Immunisation
Public health
Vaccines
Epidemiology
Vaccinology
Virology
Disease and Health Conditions
Human papillomavirus (HPV)
Emerging infectious diseases
Respiratory diseases
Country
Kenya
Sierra Leone
Somalia
Tanzania

Selected Publications

Fractional Doses of Pneumococcal Conjugate Vaccine - A Noninferiority Trial.
GALLAGHER, KE; Lucinde, R; Bottomley, C; Kaniu, M; Suaad, B; Mutahi, M; Mwalekwa, L; Ragab, S; Twi-Yeboah, L; Berkley, JA; Hamaluba, M; Karani, A; Shangala, J; OTIENDE, M; Gardiner, E; Mugo, D; SMITH, PG; Tabu, C; Were, F; Goldblatt, D; Scott, JA G;
2024
N Engl J Med
Efficacy and immunogenicity of a single dose of human papillomavirus vaccine compared to multidose vaccination regimens or no vaccination: An updated systematic review of evidence from clinical trials.
Whitworth, HS; MOUNIER-JACK, S; CHOI, EM; GALLAGHER, KE; HOWARD, N; Kelly, H; Mbwanji, G; Kreimer, AR; Basu, P; Barnabas, R; Drolet, M; Brisson, M; WATSON-JONES, D;
2024
Vaccine: X
Factors predicting mortality in hospitalised HIV-negative children with lower-chest-wall indrawing pneumonia and implications for management.
GALLAGHER, KE; Awori, JO; Knoll, MD; Rhodes, J; Higdon, MM; Hammitt, LL; Prosperi, C; Baggett, HC; Brooks, WA; Fancourt, N; Feikin, DR; Howie, SR C; Kotloff, KL; Tapia, MD; Levine, OS; Madhi, SA; Murdoch, DR; O'Brien, KL; Thea, DM; Baillie, VL; Ebruke, BE; Kamau, A; Moore, DP; Mwananyanda, L; Olutunde, EO; ... PERCH Study Group,
2024
PloS one
Symptom prevalence and secondary attack rate of SARS-CoV-2 in rural Kenyan households: A prospective cohort study.
GALLAGHER, KE; Nyiro, J; Agoti, CN; Maitha, E; Nyagwange, J; Karani, A; BOTTOMLEY, C; Murunga, N; Githinji, G; Mutunga, M; Ochola-Oyier, LI; Kombe, I; Nyaguara, A; Kagucia, EW; Warimwe, G; AGWEYU, A; Tsofa, B; Bejon, P; SCOTT, JA G; Nokes, DJ;
2023
Influenza and other respiratory viruses
Population immunity to pneumococcal serotypes in Kilifi, Kenya, before and 6 years after the introduction of PCV10 with a catch-up campaign: an observational study of cross-sectional serosurveys.
GALLAGHER, KE; ADETIFA, IM O; MBURU, C; BOTTOMLEY, C; Akech, D; Karani, A; Pearce, E; Wang, Y; Kagucia, EW; Goldblatt, D; Hammitt, LL; SCOTT, JA G;
2023
The Lancet Infectious diseases
The impact of the COVID-19 pandemic on the provision & utilisation of primary health care services in Goma, Democratic Republic of the Congo, Kambia district, Sierra Leone & Masaka district, Uganda.
Kasonia, K; TINDANBIL, D; KITONSA, J; BAISLEY, K; Zalwango, F; ENRIA, L; MANSARAY, A; James, M; Nije, Y; Tata, DT; Lawal, BJ; Drammeh, A; Lowe, B; Mukadi-Bamuleka, D; MOUNIER-JACK, S; Nakiyimba, F; Obady, P; Muhavi, J; Bangura, JS; GREENWOOD, B; Samai, M; Leigh, B; WATSON-JONES, D; Kavunga-Membo, H; RUZAGIRA, E; ... GALLAGHER, KE.
2023
PloS One
Prevalence of immunoglobulin G and M to SARS-CoV-2 and other human coronaviruses in The Democratic Republic of Congo, Sierra Leone, and Uganda: A longitudinal study.
Lawal, BJ; GALLAGHER, KE; KITONSA, J; TINDANBIL, D; Kasonia, K; Drammeh, A; Lowe, B; Mukadi-Bamuleka, D; PATTERSON, C; GREENWOOD, B; Samai, M; Leigh, B; TETTEH, KK A; RUZAGIRA, E; WATSON-JONES, D; Kavunga-Membo, H;
2023
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
The impact of the COVID-19 pandemic on vaccine coverage in Kilifi, Kenya: A retrospective cohort study.
Lucinde, RK; Karia, B; Ouma, N; Amadi, D; Nyundo, C; Mataza, C; Nyaguara, A; SCOTT, JA G; GALLAGHER, KE; Kagucia, E;
2022
Vaccine
Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in three Kenyan referral hospitals: Repeated cross-sectional surveys 2020-21.
Lucinde, RK; Mugo, D; BOTTOMLEY, C; Karani, A; Gardiner, E; Aziza, R; Gitonga, JN; Karanja, H; Nyagwange, J; Tuju, J; Wanjiku, P; Nzomo, E; Kamuri, E; Thuranira, K; Agunda, S; Nyutu, G; Etyang, AO; ADETIFA, IM O; Kagucia, E; Uyoga, S; OTIENDE, M; Otieno, E; Ndwiga, L; Agoti, CN; Aman, RA; ... GALLAGHER, KE.
2022
PLoS One
The Predictive Performance of a Pneumonia Severity Score in Human Immunodeficiency Virus-negative Children Presenting to Hospital in 7 Low- and Middle-income Countries.
GALLAGHER, KE; Knoll, MD; Prosperi, C; Baggett, HC; Brooks, WA; Feikin, DR; Hammitt, LL; Howie, SR C; Kotloff, KL; Levine, OS; Madhi, SA; Murdoch, DR; O'Brien, KL; Thea, DM; Awori, JO; Baillie, VL; Ebruke, BE; Goswami, D; Kamau, A; Maloney, SA; Moore, DP; Mwananyanda, L; Olutunde, EO; Seidenberg, P; Sissoko, S; ... SCOTT, JA G.
2019
Clinical Infectious Diseases
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