My work spans multiple disciplines (clinical trials, epidemiology, diagnostics, health economics, anthropology) but is unified by an unwavering drive to reduce mortality and morbidity from advanced HIV disease.
I joined the Faculty of Infectious and Tropical Diseases in 2017 and was based in Gaborone, Botswana for four years where I worked as the Lead Clinician for the AMBIsome Therapy Induction OptimisatioN (AMBITION) trial. AMBITION was a phase III randomised controlled trial of a single, high-dose liposomal amphotericin regimen for HIV-associated cryptococcal meningitis and recruited patients from six sites across five countries in Southern Africa.
I returned to the UK in 2021 and following the success of the trial I am co-investigator on a number of research and non-research grants aimed at maximising the impact of the AMBITION regimen in routine care settings and applying research advances in cryptococcal meningitis to other HIV-associated fungal infections.
Alongside research I work two-days a week for the NHS as a HIV and Sexual Health doctor.
I joined the Faculty of Infectious and Tropical Diseases in 2017 and was based in Gaborone, Botswana for four years where I worked as the Lead Clinician for the AMBIsome Therapy Induction OptimisatioN (AMBITION) trial. AMBITION was a phase III randomised controlled trial of a single, high-dose liposomal amphotericin regimen for HIV-associated cryptococcal meningitis and recruited patients from six sites across five countries in Southern Africa.
I returned to the UK in 2021 and following the success of the trial I am co-investigator on a number of research and non-research grants aimed at maximising the impact of the AMBITION regimen in routine care settings and applying research advances in cryptococcal meningitis to other HIV-associated fungal infections.
Alongside research I work two-days a week for the NHS as a HIV and Sexual Health doctor.
Affiliations
Department of Clinical Research
Faculty of Infectious and Tropical Diseases
Teaching
I am co-module organiser of HIV 3174 which is an intensive face-to-face module taking place in Term 3. I am a distance learning tutor on the IDM 501 HIV/AIDS module. I supervise research projects conducted by MSc students and I am currently supervising two PhD students. I have completed Module 1 and Module 2 of the Postgraduate Certificate in Learning and Teaching and am a Fellow of the Higher Education Academy.
Research
I am involved in a number of ongoing research projects including:
IMPRINT - an NIHR Global Health Research Group for HIV-associated fungal infections
SHARE-CM - an implementation project aimed at reducing mortality from cryptococcal meningitis in routine care
EFFECT - a clinical trial of combination anti-fungal therapy for cryptococcal antigenaemia
IMPALA - a clinical trial of injectable antiretroviral therapy for individuals with a history of challenges with adherence to oral treatment
IMPRINT - an NIHR Global Health Research Group for HIV-associated fungal infections
SHARE-CM - an implementation project aimed at reducing mortality from cryptococcal meningitis in routine care
EFFECT - a clinical trial of combination anti-fungal therapy for cryptococcal antigenaemia
IMPALA - a clinical trial of injectable antiretroviral therapy for individuals with a history of challenges with adherence to oral treatment
Research Area
Clinical drug trials
Clinical trials
Diagnostics
Health economics
Medical anthropology
Anthropology
Implementation science
Disease and Health Conditions
HIV/AIDS
Sexually transmitted infections
Meningitis
Country
Botswana
Uganda
Malawi
Zimbabwe
South Africa
United Kingdom
Democratic Republic of the Congo
Mozambique
Guinea
Vietnam
Region
Sub-Saharan Africa (all income levels)
Selected Publications
Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM.
2024
The Lancet Infectious Diseases
Tracking Cryptococcal Meningitis to Monitor HIV Program Success During the Treat All Era: An Analysis of National Data in Botswana.
2024
Clinical infectious diseases
Translating evidence into global impact: lessons for HIV research and policy development from the AMBITION trial.
2023
The Lancet Global health
Pathways to care with HIV-associated cryptococcal meningitis in Botswana and Uganda: Findings from a qualitative methods study.
2023
SSM - Qualitative research in health
