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Dr Jennifer Nicholas

Associate Professor

London School of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)20 7958 8119
Since I joined the LSHTM Department of Medical Statistics at the start of 2012, I have worked in clinical trials and observational research in the area of neurology. I have a particular research interest in adaptive trial design and in methods for analysis of longitudinal data.

Before I joined LSHTM I worked at King's College London conducting public health research and worked for two years as a public health epidemiologist in the NHS. I have a PhD in Epidemiology from King's College London, in which I investigated methods for analysing routinely collected electronic health care records.

Affiliations

Department of Medical Statistics
Faculty of Epidemiology and Population Health

Teaching

I am lecturer and organiser for the Linear Regression course on MSc Medical Statistics, and module organiser and tutor for Basic Statistics for Clinical Trials on the MSc Clinical Trials (distance learning). I also co-organise and lecture on the Short Course Essentials of Clinical Trials.

Research

My research includes both randomised clinical trials and non-randomised clinical studies. I have a methodological interest in clinical trial design in neurology, focusing on trials in dementia and multiple sclerosis. In particular, my research looks at the design of trials that incorporate repeated measures and medical imaging outcomes.

I have been involved in several multi-centre clinical trials. Currently my trials work focuses on researching new treatments for people with multiple sclerosis. I am working with the MS Society on the Octopus multi-arm multi-stage clinical trial to assess treatment for progressive multiple sclerosis. I am trial statistician for the MS-STAT2 randomised clinical trial, which is evaluating whether high dose simvastatin can slow progression of disability in secondary progressive multiple sclerosis. I have also worked with the LSHTM Clinical Trials Unit on trials which examine whether remote ischaemic conditioning can improve clinical outcomes in cardiovascular disease and kidney transplant.

I have an ongoing collaboration with the Dementia Research Centre, UCL, exploring genetic and other risk factors for the development of dementia and examining how dementia affects cognition, brain imaging and other biomarkers. As part of this work I am working with UCL on the Insight 46 neuroscience sub-study of the MRC National Survey of Health and Development.
Research Area
Clinical trials
Statistical methods
Randomised controlled trials
Disease and Health Conditions
Kidney disease
Neurological diseases
Cardiovascular diseases
Country
United Kingdom

Selected Publications

Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort.
Keuss, SE; Coath, W; NICHOLAS, JM; POOLE, T; Barnes, J; Cash, DM; Lane, CA; Parker, TD; Keshavan, A; Buchanan, SM; Wagen, AZ; Storey, M; Harris, M; Malone, IB; Sudre, CH; Lu, K; James, S-N; Street, R; Thomas, DL; Dickson, JC; Murray-Smith, H; Wong, A; Freiberger, T; Crutch, S; Richards, M; ... Schott, JM.
2022
NEUROLOGY
Designing Multi-arm Multistage Adaptive Trials for Neuroprotection in Progressive Multiple Sclerosis.
Li, V; Leurent, B; Barkhof, F; Braisher, M; Cafferty, F; Ciccarelli, O; Eshaghi, A; Gray, E; NICHOLAS, JM; Parmar, M; Peryer, G; Robertson, J; Stallard, N; Wason, J; Chataway, J;
2022
Neurology
Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70.
Keshavan, A; Pannee, J; Karikari, TK; Rodriguez, JL; Ashton, NJ; NICHOLAS, JM; Cash, DM; Coath, W; Lane, CA; Parker, TD; Lu, K; Buchanan, SM; Keuss, SE; James, S-N; Murray-Smith, H; Wong, A; Barnes, A; Dickson, JC; Heslegrave, A; Portelius, E; Richards, M; Fox, NC; Zetterberg, H; Blennow, K; Schott, JM;
2020
Brain
Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort.
Buchanan, SM; Parker, TD; Lane, CA; Keshavan, A; Keuss, SE; Lu, K; James, S-N; Murray-Smith, H; Wong, A; NICHOLAS, J; Cash, DM; Malone, IB; Coath, W; Thomas, DL; Sudre, C; Fox, NC; Richards, M; Schott, JM;
2020
Journal of neurology
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.
Moore, KM; NICHOLAS, J; Grossman, M; McMillan, CT; Irwin, DJ; Massimo, L; Van Deerlin, VM; Warren, JD; Fox, NC; Rossor, MN; Mead, S; Bocchetta, M; Boeve, BF; Knopman, DS; Graff-Radford, NR; Forsberg, LK; Rademakers, R; Wszolek, ZK; Van Swieten, JC; Jiskoot, LC; Meeter, LH; Dopper, EG; Papma, JM; Snowden, JS; Saxon, J; ... FTD Prevention Initiative,
2019
The Lancet. Neurology
Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort.
Lane, CA; Barnes, J; NICHOLAS, JM; Sudre, CH; Cash, DM; Malone, IB; Parker, TD; Keshavan, A; Buchanan, SM; Keuss, SE; James, S-N; Lu, K; Murray-Smith, H; Wong, A; Gordon, E; Coath, W; Modat, M; Thomas, D; Richards, M; Fox, NC; Schott, JM;
2019
JAMA neurology
Cognition at age 70: Life course predictors and associations with brain pathologies.
Lu, K; NICHOLAS, JM; Collins, JD; James, S-N; Parker, TD; Lane, CA; Keshavan, A; Keuss, SE; Buchanan, SM; Murray-Smith, H; Cash, DM; Sudre, CH; Malone, IB; Coath, W; Wong, A; Henley, SM D; Crutch, SJ; Fox, NC; Richards, M; Schott, JM;
2019
Neurology
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
Hausenloy, DJ; Kharbanda, RK; Møller, UK; Ramlall, M; Aarøe, J; Butler, R; Bulluck, H; CLAYTON, T; Dana, A; DODD, M; Engstrom, T; EVANS, R; Lassen, JF; Christensen, EF; Garcia-Ruiz, JM; Gorog, DA; Hjort, J; Houghton, RF; Ibanez, B; Knight, R; Lippert, FK; Lønborg, JT; Maeng, M; Milasinovic, D; More, R; ... CONDI-2/ERIC-PPCI Investigators,
2019
Lancet
Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study.
Lane, CA; Barnes, J; NICHOLAS, JM; Sudre, CH; Cash, DM; Parker, TD; Malone, IB; Lu, K; James, S-N; Keshavan, A; Murray-Smith, H; Wong, A; Buchanan, SM; Keuss, SE; Gordon, E; Coath, W; Barnes, A; Dickson, J; Modat, M; Thomas, D; Crutch, SJ; Hardy, R; Richards, M; Fox, NC; Schott, JM;
2019
The Lancet. Neurology
Early remote ischaemic preconditioning leads to sustained improvement in allograft function after live donor kidney transplantation: long-term outcomes in the REnal Protection Against Ischaemia-Reperfusion in transplantation (REPAIR) randomised trial.
Veighey, KV; NICHOLAS, JM; CLAYTON, T; Knight, R; ROBERTSON, S; Dalton, N; Harber, M; Watson, CJ E; De Fijter, JW; Loukogeorgakis, S; MacAllister, R;
2019
British Journal of Anaesthesia
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