Dr Richard Wall
Assistant Professor
London School of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom
Richard completed his PhD at the University of Nottingham before starting a research position in Prof Rita Tewari’s group working in a range of areas from parasite motility to cell division using the malaria model, Plasmodium berghei. He then moved to the University of Dundee to work on mode of action studies for new antiparasitic drugs in the group of Dr Susan Wyllie. This combined a myriad of genetic, proteomic and bioinformatic techniques to identify the target of new treatments against parasites that cause Chagas’ disease, Leishmaniasis, Sleeping Sickness and Malaria. Currently, he leads the lab of Prof Anil Koul at LSHTM with an aim to discover new drugs for the treatment of M. tuberculosis as well as investigating the underlying biology surrounding key drug targets.
Affiliations
Department of Infection Biology
Faculty of Infectious and Tropical Diseases
Centres
TB Centre
Antimicrobial Resistance Centre
Teaching
Richard regularly supervises lab-based summer project students and is a personal tutor for the MSc Medical Microbiology course. He also leads the group tutorials and is an assessor for the Novel Drug Discovery & AMR (3169) MSc module.
Research
Richard's primary research objective is driving various TB drug discovery projects in close collaboration with our industry partner. His other interests include using saturation mutagenesis to identify resistance-conferring mutations, the impact of target overexpression in drug resistance and drug target deconvolution of phenotypic hit compounds.
Research Area
Bacteriology
Genetics
Microbiology
Molecular biology
Parasitology
Drug discovery and development
Disease and Health Conditions
Tuberculosis
Chagas disease
Leishmaniasis
African trypanosomiasis
Malaria
Selected Publications
Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes.
2024
Nature communications
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.
2023
Science translational medicine
Short-course combination treatment for experimental chronic Chagas disease.
2023
Science translational medicine