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Dr Richard Wall

Assistant Professor

London School of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom

Richard completed his PhD at the University of Nottingham before starting a research position in Prof Rita Tewari’s group working in a range of areas from parasite motility to cell division using the malaria model, Plasmodium berghei. He then moved to the University of Dundee to work on mode of action studies for new antiparasitic drugs in the group of Dr Susan Wyllie. This combined a myriad of genetic, proteomic and bioinformatic techniques to identify the target of new treatments against parasites that cause Chagas’ disease, Leishmaniasis, Sleeping Sickness and Malaria. Currently, he leads the lab of Prof Anil Koul at LSHTM with an aim to discover new drugs for the treatment of M. tuberculosis as well as investigating the underlying biology surrounding key drug targets.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

TB Centre
Antimicrobial Resistance Centre

Teaching

Richard regularly supervises lab-based summer project students and is a personal tutor for the MSc Medical Microbiology course. He also leads the group tutorials and is an assessor for the Novel Drug Discovery & AMR (3169) MSc module.

Research

Richard's primary research objective is driving various TB drug discovery projects in close collaboration with our industry partner. His other interests include using saturation mutagenesis to identify resistance-conferring mutations, the impact of target overexpression in drug resistance and drug target deconvolution of phenotypic hit compounds.
Research Area
Bacteriology
Genetics
Microbiology
Molecular biology
Parasitology
Drug discovery and development
Disease and Health Conditions
Tuberculosis
Chagas disease
Leishmaniasis
African trypanosomiasis
Malaria

Selected Publications

Insights into the use of cytochrome bc1 inhibitors for future therapeutic strategies for tuberculosis
Pérez, CA; Lenaerts, A; Villellas, C; Guillemont, J; Dallow, J; Painter, H; Ammerman, N; Hassan, A; Golovkine, G; Brock, L; Chauffour, A; Aubry, A; Mai, T; Wong, S; CLARK, T; Nam, K; Kim, J; Choi, J; Crabbe, M; Esqui, J; Lounis, N; Stoops, B; Amssoms, K; Bartolome-Nebreda, J; Gruppo, V; ... Lamprecht, D.
2024
Research Square
An open-access dashboard to interrogate the genetic diversity of Mycobacterium tuberculosis clinical isolates.
PHELAN, J; Van den Heede, K; Masyn, S; Verbeeck, R; Lamprecht, DA; KOUL, A; WALL, RJ;
2024
Scientific reports
Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes.
Trenaman, A; Tinti, M; WALL, RJ; Horn, D;
2024
Nature communications
Targeting de novo purine biosynthesis for tuberculosis treatment
Lamprecht, D; WALL, R; Davies, C; Pearson, W; Davis, E; Willcocks, S; Dallow, J; Leemans, A; Wetzel, J; Daems, S; Sancheti, P; Monshouwer, M; Aguilar-Pérez, C; Koul, A; Sprangers, J; Fiogbe, P; Saylock, S; Ricketts, M; Huff, A; Grell, T; Draghia-Akli, R; Lin, S; Gerber, M; Dhar, N; Vos, A; ... Jackson, P.
2024
Research Square
ResMAP-a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in <i>Plasmodium</i>.
WALL, RJ; MacGowan, SA; Hallyburton, I; Syed, AJ; Ajay Castro, S; Dey, G; Milne, R; Patterson, S; PHELAN, J; Wiedemar, N; Wyllie, S;
2024
mBio
Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1.
Tulloch, LB; Tinti, M; WALL, RJ; Weidt, SK; Corpas-Lopez, V; Dey, G; Smith, TK; Fairlamb, AH; Barrett, MP; Wyllie, S;
2024
PLoS pathogens
Targeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation
Zhang, N; Samad, A; Zahedifard, F; WALL, R; Horn, D; Zoltner, M; Field, M;
2024
bioRxiv
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.
Braillard, S; Keenan, M; Breese, KJ; Heppell, J; Abbott, M; Islam, R; Shackleford, DM; Katneni, K; Crighton, E; Chen, G; Patil, R; Lee, G; White, KL; Carvalho, S; WALL, RJ; Chemi, G; Zuccotto, F; González, S; Marco, M; Deakyne, J; Standing, D; Brunori, G; Lyon, JJ; Castañeda-Casado, P; Camino, I; ... Chatelain, E.
2023
Science translational medicine
Short-course combination treatment for experimental chronic Chagas disease.
González, S; WALL, RJ; Thomas, J; Braillard, S; Brunori, G; Camino Díaz, I; Cantizani, J; Carvalho, S; Castañeda Casado, P; Chatelain, E; Cotillo, I; Fiandor, JM; FRANCISCO, AF; Grimsditch, D; Keenan, M; KELLY, JM; Kessler, A; Luise, C; Lyon, JJ; MacLean, L; Marco, M; Martin, JJ; Martinez Martinez, MS; Paterson, C; Read, KD; ... De Rycker, M.
2023
Science translational medicine
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