Dr Vanessa Yardley
Assistant Professor
A member of staff and a student at LSHTM since the early 1990's, working in a kinetoplastid drug discovery group. Collaborating with over 100 stakeholders during this time, across academia and Pharma, to identify new therapies for NTDS and malaria.
Affiliations
Department of Infection Biology
Faculty of Infectious and Tropical Diseases
Centres
Antimicrobial Resistance Centre
Teaching
Module Organiser for core module in Parasitology & Entomology for MSc students.
Contributing lecturer, kinetoplastid and NTD chemotherapy, on other MSc modules.
Co-organiser of MSc Field Trip (1 week)
Lead educator and developer of KalalCORE MOOC ( Control & Treatment of Visceral Leishmaniasis)
Contributing lecturer, kinetoplastid and NTD chemotherapy, on other MSc modules.
Co-organiser of MSc Field Trip (1 week)
Lead educator and developer of KalalCORE MOOC ( Control & Treatment of Visceral Leishmaniasis)
Research
Drug discovery and development
In vitro and in vivo models of infection to identify novel compounds and regimens to treat kinetoplastid infections. Use of PK PD sampling to inform drug activity in models and development of techniques to better predict outcomes in human infection.
In vitro and in vivo models of infection to identify novel compounds and regimens to treat kinetoplastid infections. Use of PK PD sampling to inform drug activity in models and development of techniques to better predict outcomes in human infection.
Research Area
Chemotherapy
Complex interventions
Diagnostics
Drug discovery and development
Drug resistance
Pharmacokinetics
Protozoa
Trypanosomes
Cell biology
Immunopathology
Parasitology
Pathology
Pharmacology
Disease and Health Conditions
African trypanosomiasis
Chagas Disease
Leishmaniasis
Malaria
Neglected Tropical Diseases (NTDs)
Infectious diseases
Emerging infectious diseases
Skin diseases
Country
Afghanistan
Australia
Bangladesh
Belgium
Brazil
Colombia
Ethiopia
France
Germany
India
Iran
Japan
Nepal
New Zealand
Pakistan
South Sudan
Sudan
Syrian Arab Republic
Tunisia
United Kingdom
Region
Latin America & Caribbean (all income levels)
Sub-Saharan Africa (all income levels)
Selected Publications
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.
2023
Science translational medicine
Efficacy of oleylphosphocholine in experimental cutaneous leishmaniasis.
2023
The Journal of antimicrobial chemotherapy
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
2021
Journal of Medicinal Chemistry
Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.
2021
PLoS neglected tropical diseases
Novel Linker Variants of Antileishmanial/Antitubercular 7-Substituted 2-Nitroimidazooxazines Offer Enhanced Solubility.
2021
ACS medicinal chemistry letters