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Evidence underpinning e-cigarette recommendations questioned

Concern over Public Health England?s recent support for e-cigarettes.

Following Public Health England's (PHE) recent endorsement of the use of e-cigarettes as an aid to quitting smoking, experts have questioned the evidence on safety and effectiveness used to underpin the recommendations.

In a new analysis in The BMJ, Professor Martin McKee at the London School of Hygiene & Tropical Medicine and Professor Simon Capewell at the University of Liverpool, argue that the available evidence about e-cigarettes "suggests that the debate is far from over and questions remain about their benefits and harms."

The PHE report concludes that e-cigarettes are much safer than conventional cigarettes. It also says there is no evidence that e-cigarettes give children a "gateway" into smoking.

Some of the findings have been welcomed by Action on Smoking and Health (ASH) and the Royal College of Physicians of London. But other leading health bodies - including the British Medical Association, the US Centers for Disease Control and Prevention, and the World Health Organization - have expressed caution.

So does the available evidence show clearly that e-cigarettes are as effective as established quitting aids, ask Prof McKee and Prof Capewell? Unfortunately not, they say.  

The authors state a recent Cochrane review, widely cited in the report, concluded the evidence was of "low or very low quality" by recognised standards. They add that a recent systematic review, which the PHE report surprisingly fails to cite, also found serious methodological problems in many of the studies it reviewed, and one third of the studies (34%) were published by authors with conflicts of interest.

The headline message from the PHE report that "best estimates show e-cigarettes are 95% less harmful to your health than normal cigarettes" is also questioned by the authors, who point out that this figure comes from a single meeting of 12 people, involving several known e-cigarette champions and sponsored by companies with links to the tobacco industry.

While the PHE report asserts that the available evidence suggests that e-cigarettes are not currently re-normalising smoking among children and young people in the UK, the authors point out that experimentation with e-cigarettes among young people in England is "worryingly high" and "this remains a major concern for health professionals and parents."

They describe the report's dismissal of the possibility that e-cigarettes may be a gateway to smoking as "premature." And argue that the report has many other omissions, such as concerns about product safety, and the lack of evidence of risks from long term dual use with conventional cigarettes.

In response to the PHE report summary stating that "the accuracy of nicotine content labelling currently raises no major concerns," the authors say: "Surely, England's leading public health agency cannot be indifferent to a situation where consumer product information is known to be wildly inaccurate?"

In 2017, the European Union Tobacco Products Directive will come into force, with substantial restrictions on e-cigarettes. "These restrictions will hopefully limit the negative effect of this flawed PHE report," say the authors.

"Meanwhile, directors of public health and the wider community desperately need advice on e-cigarettes that is evidence based and free from any suspicion of influence by vested interests," they conclude.

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