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Dr David Lawrence

Clinical Research Physician

United Kingdom

My work spans multiple disciplines (clinical trials, epidemiology, diagnostics, health economics, anthropology) but is unified by an unwavering drive to reduce mortality and morbidity from advanced HIV disease.

I joined the Faculty of Infectious and Tropical Diseases in 2017 and was based in Gaborone, Botswana for four years where I worked as the Lead Clinician for the AMBIsome Therapy Induction OptimisatioN (AMBITION) trial. AMBITION was a phase III randomised controlled trial of a single, high-dose liposomal amphotericin regimen for HIV-associated cryptococcal meningitis and recruited patients from six sites across five countries in Southern Africa.

I returned to the UK in 2021 and following the success of the trial I am co-investigator on a number of research and non-research grants aimed at maximising the impact of the AMBITION regimen in routine care settings and applying research advances in cryptococcal meningitis to other HIV-associated fungal infections.

Alongside research I work two-days a week for the NHS as a HIV and Sexual Health doctor.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I am co-module organiser of HIV 3174 which is an intensive face-to-face module taking place in Term 3. I am a distance learning tutor on the IDM 501 HIV/AIDS module. I supervise research projects conducted by MSc students and I am currently supervising two PhD students. I have completed Module 1 and Module 2 of the Postgraduate Certificate in Learning and Teaching and am a Fellow of the Higher Education Academy.

Research

I am involved in a number of ongoing research projects including:

IMPRINT - an NIHR Global Health Research Group for HIV-associated fungal infections
SHARE-CM - an implementation project aimed at reducing mortality from cryptococcal meningitis in routine care
EFFECT - a clinical trial of combination anti-fungal therapy for cryptococcal antigenaemia
IMPALA - a clinical trial of injectable antiretroviral therapy for individuals with a history of challenges with adherence to oral treatment
Research Area
Clinical drug trials
Clinical trials
Diagnostics
Health economics
Medical anthropology
Anthropology
Implementation science
Disease and Health Conditions
HIV/AIDS
Sexually transmitted infections
Meningitis
Country
Botswana
Uganda
Malawi
Zimbabwe
South Africa
United Kingdom
Democratic Republic of the Congo
Mozambique
Guinea
Vietnam
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis.
Stott, KE; Mohabir, JT; Bowers, K; Tenor, JL; Toffaletti, DL; Unsworth, J; Jimenez-Valverde, A; Ahmadu, A; Moyo, M; Gondwe, E; Chimang'anga, W; Chasweka, M; LAWRENCE, DS; JARVIS, JN; Harrison, T; Hope, W; Lalloo, DG; Mwandumba, HC; Perfect, JR; Cuomo, CA; AMBITION Study Group,;
2024
mBio
Implementation of single high-dose liposomal amphotericin B based induction therapy for treatment of HIV-associated cryptococcal meningitis in Uganda: a comparative prospective cohort study.
Gakuru, J; Kagimu, E; Dai, B; Okurut, S; Nsangi, L; Bahr, NC; Okirwoth, M; Namuju, OC; JARVIS, JN; LAWRENCE, DS; Ahimbisibwe, C; ELLIS, J; Tadeo, KK; Boulware, DR; Meya, DB; Tugume, L;
2024
Clinical Infectious Diseases
Personalised risk prediction tools for cryptococcal meningitis mortality to guide treatment stratification; a pooled analysis of two randomised-controlled trials
Samuels, TH A; Molloy, SF; LAWRENCE, DS; Loyse, A; Kanyama, C; Heyderman, RS; Lai, WS; Mfinanga, S; Lesikari, S; Chanda, D; Kouanfack, C; Temfack, E; Lortholary, O; Hosseinipour, MC; Chan, AK; Meya, DB; Boulware, DR; Mwandumba, HC; Meintjes, G; Muzoora, C; Mosepele, M; Ndhlovu, CE; Youssouf, N; Harrison, TS; JARVIS, JN; ... Gupta, RK.
2024
medRxiv
Two-drug regimens for the treatment of HIV in Africa.
Mambule, I; Norcross, C; Achieng Ombajo, L; Sokhela, S; Laker Odongpiny, EA; Owarwo, N; LAWRENCE, DS; RUZAGIRA, E; CRESSWELL, FV;
2024
The Lancet HIV
Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM.
Chang, CC; Harrison, TS; Bicanic, TA; Chayakulkeeree, M; Sorrell, TC; Warris, A; Hagen, F; Spec, A; Oladele, R; Govender, NP; Chen, SC; Mody, CH; Groll, AH; Chen, Y-C; Lionakis, MS; Alanio, A; Castañeda, E; Lizarazo, J; Vidal, JE; Takazono, T; Hoenigl, M; Alffenaar, J-W; Gangneux, J-P; Soman, R; Zhu, L-P; ... Perfect, JR.
2024
The Lancet Infectious Diseases
Development and validation of quantitative PCR assays for HIV-associated cryptococcal meningitis in sub-Saharan Africa: a diagnostic accuracy study.
Mbangiwa, T; Sturny-Leclère, A; Lechiile, K; Kajanga, C; Boyer-Chammard, T; Hoving, JC; Leeme, T; Moyo, M; Youssouf, N; LAWRENCE, DS; Mwandumba, H; Mosepele, M; Harrison, TS; JARVIS, JN; Lortholary, O; Alanio, A; AMBITION Study Group,;
2024
The Lancet microbe
Tracking Cryptococcal Meningitis to Monitor HIV Program Success During the Treat All Era: An Analysis of National Data in Botswana.
MILBURN, J; Ntwayagae, O; Suresh, R; Ngoni, K; Northcott, C; Penney, J; Kinsella, M; Mechie, I; Ensor, S; Thamae, G; Leeme, T; LAWRENCE, DS; Chebani, T; GRINT, D; Tenforde, MW; Avalos, A; Ramaabya, D; Ogando, J; Mokomane, M; Mine, M; JARVIS, JN;
2024
Clinical infectious diseases
Cryptococcal meningitis.
Tugume, L; Ssebambulidde, K; Kasibante, J; ELLIS, J; Wake, RM; Gakuru, J; LAWRENCE, DS; Abassi, M; Rajasingham, R; Meya, DB; Boulware, DR;
2023
Nature reviews Disease primers
Translating evidence into global impact: lessons for HIV research and policy development from the AMBITION trial.
JARVIS, JN; Chou, R; Harrison, TS; LAWRENCE, DS; Muthoga, C; Mupeli, K; Meya, DB; Mwandumba, HC; Kanyama, C; Meintjes, G; Leeme, TB; Ndhlovu, CE; Beattie, P; Sued, O; Pérez Casas, C; Makanga, M; Ford, N;
2023
The Lancet Global health
Pathways to care with HIV-associated cryptococcal meningitis in Botswana and Uganda: Findings from a qualitative methods study.
LAWRENCE, DS; SSALI, A; Moshashane, N; Nabaggala, G; Maphane, L; Harrison, TS; Meya, D; JARVIS, JN; SEELEY, J;
2023
SSM - Qualitative research in health
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