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Dr Claire Calderwood

Clinical Research Fellow in Training

United Kingdom

I am Wellcome Trust Clinical PhD fellow in Global Health Research at LSHTM and respiratory physician in higher speciality training in the UK. For my PhD I am based in Zimbabwe with the THRU Zim team. My research is investigating chronic disease clustering within TB-affected households as a nested sub-study in ERASE-TB and seeks to develop an integrated health check for TB-affected households. More broadly, I am interested in approaches to address infectious and non-infectious chronic disease morbidity and mortality, particularly chronic respiratory disease including post-TB lung disease, in resource-limited settings.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Research

TB is a disease of social, biological and economic vulnerability. The same conditions which put people at risk of TB increase the risk of chronic disease and multimorbidity, whilst presenting financial barriers to accessing healthcare. These underlying causes rarely affect an individual in isolation, they cluster in households and communities. Implementing screening for high-risk contacts of people with TB is a core component of the global ‘End TB’ strategy.

My research hypothesises that TB household contacts are a key risk group both for TB and chronic diseases, but that they have poor healthcare access; and that integrating chronic disease screening with that for TB is an effective way to address the large unmet burden of non-communicable disease morbidity and mortality in southern Africa.

Embedded in a large TB household contact screening study (ERASE-TB) my PhD research has three components. Firstly, I am exploring patterns of disease clustering in individuals and households affected by TB in three African countries (Zimbabwe, Tanzania and Mozambique). Secondly, I am exploring the social context of health screening through qualitative research with members of TB-affected households, healthcare workers and policy makers in Zimbabwe. These data will be used to, thirdly, develop and pilot an integrated health screening package for TB-affected households in Zimbabwe.

I also support the Vaxef study, evaluating the real-world effectiveness of COVID-19 vaccines among high-risk groups in Zimbabwe, and was part of the ICAROZ team, delivering occupational health checks for healthcare workers in Zimbabwe during the COVID-19 pandemic.
Research Area
Epidemiology
Implementation science
Disease and Health Conditions
Tuberculosis
Lung diseases
Non-communicable diseases
Country
Zimbabwe
Mozambique
Tanzania
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Resolution of tuberculosis blood RNA signatures fails to discriminate persistent sputum culture positivity after 8 weeks of anti-tuberculous treatment.
CALDERWOOD, CJ; Sanchez Martinez, A; Greenan-Barrett, J; Turner, CT; Oguti, B; Roe, JK; Gupta, R; Martineau, AR; Noursadeghi, M;
2024
The European respiratory journal
HIV, malnutrition, and noncommunicable disease epidemics among tuberculosis-affected households in east and southern Africa: A cross-sectional analysis of the ERASE-TB cohort.
CALDERWOOD, CJ; Marambire, ET; Larsson, L; Banze, D; Mfinanga, A; Nhamuave, C; Appalarowthu, T; Mugava, M; Ribeiro, J; Towo, PE; Madziva, K; DIXON, J; Held, K; Minja, LT; Mutsvangwa, J; Khosa, C; Heinrich, N; FIELDING, K; KRANZER, K; ERASE-TB consortium,;
2024
PLoS medicine
Interdisciplinary perspectives on multimorbidity in Africa: Developing an expanded conceptual model.
DIXON, J; Morton, B; Nkhata, MJ; Silman, A; Simiyu, IG; Spencer, SA; Van Pinxteren, M; Bunn, C; CALDERWOOD, C; CHANDLER, CI R; Chikumbu, E; CRAMPIN, AC; Hurst, JR; JOBE, M; Kengne, AP; Levitt, NS; Moshabela, M; Owolabi, M; Peer, N; Phiri, N; Singh, SJ; Tamuhla, T; Tembo, M; Tiffin, N; Worrall, E; ... Limbani, F.
2024
PLOS global public health
ERASE-TB: cross-sectional HIV, malnutrition and non-communicable diseases dataset
CALDERWOOD, C;
2024
London School of Hygiene & Tropical Medicine
Longitudinal lung function trajectories in response to azithromycin therapy for chronic lung disease in children with HIV infection: a secondary analysis of the BREATHE trial.
MADANHIRE, T; McHugh, G; SIMMS, V; Ngwira, L; Gonzalez-Martinez, C; Semphere, R; Moyo, B; CALDERWOOD, C; Nicol, M; Bandason, T; Odland, JO; Rehman, AM; FERRAND, RA;
2024
BMC pulmonary medicine
Need for high-resolution observational cohort studies to understand the natural history of tuberculosis.
Larsson, L; CALDERWOOD, CJ; Gupta, RK; Khosa, C; KRANZER, K;
2024
The Lancet. Microbe
Blood RNA signatures outperform CRP triage of tuberculosis lymphadenitis and pericarditis.
Mann, T; Minnies, S; Gupta, RK; Reeve, BW; Nyawo, G; Palmer, Z; Naidoo, C; Doubell, A; Pecararo, A; John, T-J; Schubert, P; CALDERWOOD, CJ; Chandran, A; Theron, G; Noursadeghi, M;
2024
medRxiv
Higher loss of livelihood and impoverishment in households affected by tuberculosis compared to non-tuberculosis affected households in Zimbabwe: A cross-sectional study.
TIMIRE, C; HOUBEN, RM G J; Pedrazzoli, D; FERRAND, RA; CALDERWOOD, CJ; BOND, V; Mbiba, F; KRANZER, K;
2024
PLOS global public health
Blood RNA biomarkers for tuberculosis screening in people living with HIV before antiretroviral therapy initiation: a diagnostic accuracy study.
Mann, T; Gupta, RK; Reeve, BW P; Ndlangalavu, G; Chandran, A; Krishna, AP; CALDERWOOD, CJ; Tshivhula, H; Palmer, Z; Naidoo, S; Mbu, DL; Theron, G; Noursadeghi, M;
2024
The Lancet. Global health
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