My research includes both randomised clinical trials and non-randomised clinical studies. I have a methodological interest in clinical trial design in neurology, focusing on trials in dementia and multiple sclerosis. In particular, my research looks at the design of trials that incorporate repeated measures and medical imaging outcomes.

I have been involved in several multi-centre clinical trials. Currently my trials work focuses on researching new treatments for people with multiple sclerosis. I am working with the MS Society on the Octopus multi-arm multi-stage clinical trial to assess treatment for progressive multiple sclerosis. I am trial statistician for the MS-STAT2 randomised clinical trial, which is evaluating whether high dose simvastatin can slow progression of disability in secondary progressive multiple sclerosis. I have also worked with the LSHTM Clinical Trials Unit on trials which examine whether remote ischaemic conditioning can improve clinical outcomes in cardiovascular disease and kidney transplant.

I have an ongoing collaboration with the Dementia Research Centre, UCL, exploring genetic and other risk factors for the development of dementia and examining how dementia affects cognition, brain imaging and other biomarkers. As part of this work I am working with UCL on the Insight 46 neuroscience sub-study of the MRC National Survey of Health and Development.