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Mr Prachand Issarapu

Research Fellow - Bioinformatics

United Kingdom

Affiliations

MRC Unit The Gambia at LSHTM

Selected Publications

Maternal age is related to offspring DNA methylation: A meta-analysis of results from the PACE consortium.
Yeung, E; Biedrzycki, RJ; Gómez Herrera, LC; ISSARAPU, P; Dou, J; Marques, IF; Mansuri, SR; Page, CM; Harbs, J; Khodasevich, D; Poisel, E; Niu, Z; Allard, C; Casey, E; Berstein, FM; Mancano, G; Elliott, HR; Richmond, R; He, Y; Ronkainen, J; Sebert, S; Bell, EM; Sharp, G; Mumford, SL; Schisterman, EF; ... Guan, W.
2024
Aging cell
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation.
Li, S; Spitz, N; Ghantous, A; Abrishamcar, S; Reimann, B; Marques, I; SILVER, MJ; Aguilar-Lacasaña, S; Kitaba, N; Rezwan, FI; Röder, S; Sirignano, L; Tuhkanen, J; Mancano, G; Sharp, GC; Metayer, C; Morimoto, L; Stein, DJ; Zar, HJ; Alfano, R; Nawrot, T; Wang, C; Kajantie, E; Keikkala, E; Mustaniemi, S; ... Wiemels, JL.
2024
Communications biology
DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood.
ISSARAPU, P; Arumalla, M; Elliott, HR; Nongmaithem, SS; Sankareswaran, A; Betts, M; Sajjadi, S; Kessler, NJ; Bayyana, S; Mansuri, SR; Derakhshan, M; Krishnaveni, GV; Shrestha, S; Kumaran, K; Di Gravio, C; Sahariah, SA; Sanderson, E; RELTON, CL; Ward, KA; Moore, SE; PRENTICE, AM; Lillycrop, KA; Fall, CH D; SILVER, MJ; Chandak, GR; ... EMPHASIS study group,
2023
Nature communications
Environmentally sensitive hotspots in the methylome of the early human embryo.
SILVER, MJ; Saffari, A; Kessler, NJ; Chandak, GR; Fall, CH D; ISSARAPU, P; Dedaniya, A; Betts, M; Moore, SE; Routledge, MN; Herceg, Z; Cuenin, C; Derakhshan, M; James, PT; Monk, D; PRENTICE, AM;
2022
eLife
DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study.
Antoun, E; ISSARAPU, P; Di Gravio, C; Shrestha, S; Betts, M; Saffari, A; Sahariah, SA; Sankareswaran, A; Arumalla, M; PRENTICE, AM; Fall, CH D; SILVER, MJ; Chandak, GR; Lillycrop, KA; EMPHASIS study group,;
2022
Clinical epigenetics
Effect of maternal preconceptional and pregnancy micronutrient interventions on children's DNA methylation: Findings from the EMPHASIS study.
Saffari, A; Shrestha, S; ISSARAPU, P; Sajjadi, S; Betts, M; Sahariah, SA; Tomar, AS; JAMES, P; Dedaniya, A; Yadav, DK; Kumaran, K; PRENTICE, AM; Lillycrop, KA; Fall, CH D; Chandak, GR; SILVER, MJ; EMPHASIS Study Group,;
2020
The American Journal of Clinical Nutrition
Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism.
JAMES, P; Sajjadi, S; Tomar, AS; Saffari, A; Fall, CH D; PRENTICE, AM; Shrestha, S; Issarapu, P; Yadav, DK; Kaur, L; Lillycrop, K; SILVER, M; Chandak, GR; EMPHASIS study group,;
2018
International journal of epidemiology
Protocol for the EMPHASIS study; epigenetic mechanisms linking maternal pre-conceptional nutrition and children's health in India and Sub-Saharan Africa.
Chandak, GR; SILVER, MJ; Saffari, A; Lillycrop, KA; Shrestha, S; Sahariah, SA; Di Gravio, C; GOLDBERG, G; Tomar, AS; Betts, M; Sajjadi, S; Acolatse, L; JAMES, P; Issarapu, P; Kumaran, K; Potdar, RD; PRENTICE, AM; Fall, CH;
2017
BMC nutrition
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