This seminar will review recent direct and indirect evidence on the burden of subclinical TB and its contribution to transmission.
Tuberculosis with atypical or minimal symptoms has been known to exist ever since the discovery of the X-ray in 1895. Neglected by the global DOTS strategy, it has regained interest as a potentially important source of transmission and future morbidity. This seminar will review recent direct and indirect evidence on the burden of subclinical TB and its contribution to transmission. It will highlight gaps in our knowledge as well as limitations of the available data with regard to study designs, case definitions, reliability of symptom measurement and potential biases in measurement of transmission. Finally, it will discuss options for earlier diagnosis and treatment of this still rather elusive condition.
Speaker
Frank Cobelens, University of Amsterdam
Frank Cobelens, epidemiologist and professor of Global Health at the University of Amsterdam, has worked on tuberculosis for nearly 30 years. His recent interests are in diagnostic evaluation, drivers and markers of TB disease progression and evaluation of (new) TB vaccines.
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