London School of Hygiene & Tropical Medicine

Tell us about your current research

My current research focuses on improving our understanding of vaccine responses and accelerating vaccine development for neglected tropical diseases like schistosomiasis. One key project I have been involved in is the Population Differences in Vaccine Immune Responses (POPVAC) project, which explored how chronic infections, like malaria and schistosomiasis, influence vaccine responses in adolescents across Uganda. Through this project, we have analysed how intensive treatment for helminths, intermittent preventive malaria therapy and BCG revaccination influence immune responses to unrelated vaccines. I am also part of a project that is aiming to fast-track the development of vaccines for schistosomiasis by conducting controlled human infection studies tailored to endemic settings. Ultimately, my work is about bridging the gap between laboratory findings and real-world vaccine strategies, ensuring that our efforts benefit communities in low-resource settings. It’s rewarding to contribute to science that has the potential to transform global health outcomes.

How did you first become interested in vaccines?

My fascination with vaccines began during my post-graduate studies in immunology and clinical microbiology, at Makerere University. I was captivated by how vaccines work to prevent disease and, most importantly, how they have the power to save millions of lives worldwide. As my career progressed, I witnessed the devastating impact of infectious diseases in African settings. This experience fuelled my desire to contribute to solutions that address these challenges, with vaccines standing out as one of the most effective tools. I am passionate about this field because of its direct impact on public health and its potential to shape vaccination strategies that are both effective and equitable for African populations.

What do you hope to achieve during your time working with the vaccine theme at the MRC unit Uganda?

I hope to contribute to groundbreaking research that deepens our understanding of vaccine efficacy and safety, particularly in African populations. A key part of this involves pursuing PhD studies to explore the role of factors like the gut microbiome in shaping vaccine responses. I believe this area of research holds great potential to improve vaccine effectiveness, not just in resource-limited settings but on a global scale. In addition, I aim to continue supporting capacity-building efforts by mentoring and training junior scientists, interns, and visiting researchers. This is central to fostering a collaborative research environment and building a sustainable workforce of skilled scientists for the future. Lastly, I aspire to lead independent research projects in vaccine immunology, addressing critical questions that have a direct impact on improving health outcomes for our local communities. Through these efforts, I hope to advance both science and the Unit's mission to deliver meaningful contributions to public health.

What do you find particularly exciting working as a member of the Vaccine Centre?

What I find most exciting about being part of the Vaccine Centre is the chance to work with experts from so many different fields. This interdisciplinary approach not only broadens my scientific perspective but also drives innovative solutions to some of the biggest challenges in vaccine research. I am particularly passionate about the focus on vaccine responses in African populations because it allows us to tackle unique issues like endemic diseases, nutritional factors, and co-infections that directly influence vaccine efficacy. Knowing that this work has the potential to make a real difference in public health in the region is incredibly rewarding. I am also inspired by the opportunity to be involved in cutting-edge advancements like mRNA vaccine platforms. It is exciting to contribute to research that has a tangible impact on vaccine policy and health practices. Beyond the science, the Centre provides such a supportive environment for personal and professional growth. I’m constantly learning new techniques, refining my leadership skills, and engaging in research that aligns perfectly with my long-term goals in vaccine immunology.

Where do you think your research will take you?

As I continue to grow, I aim to take on more leadership in independent research projects, particularly in areas that intersect with immunology and infectious diseases. Through my doctoral research, I plan to contribute to the global understanding of vaccine immunity, laying the groundwork for my future career as a leading researcher in vaccine science. Another key aspect of my research is collaborating with local and international experts, fostering partnerships that will further enhance the quality and reach of my research.

What are some of the real-life implications of your work?

One of the most direct real-life implications of my work is the potential to improve vaccine efficacy in African populations, where co-infections and nutritional factors may affect how vaccines perform. By understanding the specific immune responses in these populations, I can contribute to the development of more targeted and effective vaccines that will better protect our populations, with vulnerable groups included. My research into the immunological mechanisms of vaccines, particularly in relation to the gut microbiome and other underlying health factors, has the potential to address major public health challenges such as vaccine failure or suboptimal responses. This will directly impact global health strategies, ensuring that vaccines provide the maximum benefit to populations in need.

My involvement in biosafety committees and ensuring that proper protocols are followed during vaccine-related research ensures that the work is not only scientifically sound but also safe for both researchers and the populations they aim to protect.

What do you like doing in your spare time?

I love travelling, spending quality time with my family as well as engaging in hobbies like listening to music, cleaning and organising and trying out different food recipes.

How can people get/ stay in touch with you?

I am always happy to connect and collaborate! You can reach me via email. You can also connect with me on LinkedIn at Jacent Nassuuna or follow me on X (formerly Twitter) as @JacentNMuddu.