My main research area is the evaluation and optimisation of vaccine interventions. For S. pneumoniae this includes using mathematical models to help better understand how to use existing pneumococcal vaccine more efficiently, ie reducing cost and maximising impact, and to help designing optimal future vaccine formulations. 

My team and I work closely with a range of international partners including on vaccine trials and their interpretation in Vietnam and in humanitarian crises settings. My other interests include real-time evaluation of pandemic pathogens  as well as evolution and mitigation of AMR, assessing and
predicting the impact of vaccines against seasonal influenza, HiB, varicella zoster, melioidosis, non-typhoid salmonella, RSV, hand foot and mouth disease, malaria and dengue.