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Dr Tegwen Marlais

Research Fellow

United Kingdom

I am a Research Fellow in the Infection Biology Department.

I have a background in parasitology and diagnostics development for infectious diseases, particularly immunodiagnostics, which is the basis of my lab work.

I am Project Coordinator for the MALCOV study on the effect of Plasmodium infection (malaria) on COVID-19 disease progression and outcome. The MALCOV study is taking place in Kenya and Burkina Faso and includes measurement of many immunological and clinical parameters, as well as virus and parasite characteristics, to untangle the interaction between these components.

My other recent work was a study called Markers of Severity Diagnostics for Evaluating Fever (Mos-Def) which was nested within the large multi-country FIEBRE study on fever aetiology. My work involved developing a multiplex bead-based immunoassay on the Luminex platform to detect molecules released by the immune system during infection. By quantifying these markers in blood samples from the FIEBRE study, we are analysing which markers are useful to provide a prognosis for fever cases and which markers can differentiate between causes of fever such as bacterial, viral or parasitic.

My PhD, at LSHTM, was on diagnostics development for two parasitic infections: strongyloidiasis caused by the nematode (worm) Strongyloides stercoralis, and visceral leishmaniasis caused by the protozoan Leishmania. This included laboratory and field work in India and Guinea Bissau, as well as computational methods of antigen discovery using large open-access data sets such as genomes, proteomes and transcriptomes.

In addition to conducting research, I act as a personal tutor to students on the MSc Control of Infectious Diseases, co-supervise a PhD student and MSc research projects, act as a tutor for Distance Learning modules. I contribute to teaching on MSc Control of Infectious Disease, and MSc One Health. I have completed module 1 of the Post Graduate Certificate in Learning and Teaching (PG-CILT).

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Research

Biomarkers, diagnostics, serology, parasitic and infectious diseases, epidemiology.
Research Area
Serology, vaccines
Immunoepidemiology
Immunity
Disease and Health Conditions
Malaria
Soil transmitted helminths
Intestinal helminths
COVID-19
Fever
Country
Kenya
Burkina Faso
Ethiopia
Madagascar

Selected Publications

Predicting mortality in febrile adults: comparative performance of the MEWS, qSOFA, and UVA scores using prospectively collected data among patients in four health-care sites in sub-Saharan Africa and South-Eastern Asia.
LAL, S; Luangraj, M; Keddie, SH; Ashley, EA; Baerenbold, O; Bassat, Q; BRADLEY, J; Crump, JA; Feasey, NA; Green, EW; Kain, KC; Olaru, ID; Lalloo, DG; ROBERTS, CH; Mabey, DC W; Moore, CC; Hopkins, H; Febrile Illness Evaluation in a Broad Range of End,;
2024
eClinicalMedicine
Microverse
Ramachandra, M; Khan, A; Roy, K;
2024
Having malaria at the same time as COVID-19 alters SARS-CoV-2 antibody response and is dependent on
age
MARLAIS, T; DRAKELEY, C;
2023
ASTMH
A comparative 'omics' approach for prediction of candidate Strongyloides stercoralis diagnostic coproantigens.
MARLAIS, T; Bickford-Smith, J; Talavera-López, C; Le, H; Chowdhury, F; MILES, MA;
2023
PLoS neglected tropical diseases
BLAST results: S. stercoralis orthologues of the S. ratti E/S proteome
MARLAIS, T; Bickford-Smith, J; Talavera-López, C; Le, H; Chowdhury, F; MILES, MA;
2023
PLOS Neglected Tropical Diseases
Candidate coproantigen sequences in fasta format
MARLAIS, T; Bickford-Smith, J; Talavera-López, C; Le, H; Chowdhury, F; MILES, MA;
2023
PLOS Neglected Tropical Diseases
Predicted epitopes in S. stercoralis proteins using BepiPred and bcepred
MARLAIS, T; Bickford-Smith, J; Talavera-López, C; Le, H; Chowdhury, F; MILES, MA;
2023
PLOS Neglected Tropical Diseases
Protein identity, features and gene expression levels of S. stercoralis orthologues of S. ratti E/S proteomic data
MARLAIS, T; Bickford-Smith, J; Talavera-López, C; Le, H; Chowdhury, F; MILES, MA;
2023
PLOS Neglected Tropical Diseases
DEVELOPMENT AND PERFORMANCE EVALUATION OF A LOW-COST, HIGH THROUGHPUT, MULTIPLEX IMMUNOASSAY OF THIRTEEN FEVER SEVERITY AND ETIOLOGY MARKERS
MARLAIS, T; Handley, BL; Ashley, EA; Drakeley, C; Luangraj, M; Lubell, Y; Mabey, D; Mayxay, M; Newton, PN; HOPKINS, H; ROBERTS, CH;
2021
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
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