Prof Nick Dorrell

Professor of Bacterial Pathogenesis

United Kingdom

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Nick

Nick Dorrell originally trained as a pharmacist, obtaining a Bachelor of Pharmacy degree from the University of Bath in 1988 and completing his pre-registration training at King's College Hospital in 1989. After two years working in hospital pharmacy, he returned to Bath to study DNA repair in Escherichia coli, completing his PhD in 1993. He joined Brendan Wren's research group at St Bartholomew's Hospital in January 1994, working on many different aspects of bacterial pathogenicity of Brucella species, Yersinia species and Helicobacter pylori. He joined the LSHTM in July 1999 and is continuing to study the pathogenicity of both H. pylori and predominantly Campylobacter jejuni.

Affiliations

Department of Infection Biology

Faculty of Infectious and Tropical Diseases

Teaching

From September 2016 to September 2022, Nick was the Taught Programme Director for the Faculty of Infectious & Tropical Diseases, with oversight of all teaching on the MSc Programmes (both Intensive and Distance Learning) and Short Courses run by the Faculty. Previously Nick was the Programme Director for the MSc in Medical Microbiology (https://www.lshtm.ac.uk/study/masters/medical-microbiology) from 2005 to 2016. During this time, he also acted as Module Organiser for the MSc Modules on Bacteriology, Clinical Bacteriology and Clinical Virology and also lectured on the MSc Module Advanced Training in Molecular Biology. He chaired the Course Committee and was a member of the Exam Board for the MSc in Medical Microbiology.

During the 2023-2024 academic year, Nick lectures on the MSc Modules on Bacteriology and Advanced Training in Molecular Biology.

Nick currently supervises one PhD student and also supervises MSc research projects at the LSHTM.

Nick successfully completed the Professional Certificate in Teaching and Learning in Higher and Professional Education (with Distinction) at the Institute of Education (University of London) in 2006 and became a Fellow of The Higher Education Academy in 2007.

Research

Current research interests cover five main areas of bacterial pathogenesis:-

i) Role of outer membrane vesicles during C. jejuni infection;
ii) C. jejuni oxidative and aerobic stress responses;
iii) Mechanisms of C. jejuni invasion of intestinal epithelial cells;
iv) Role of the C. jejuni Type VI Secretion System;
v) The innate immune response to C. jejuni infection.

A long term interest has been developing new technology associated with functional genomic research. Nick was involved in the construction of the first DNA microarray produced by the Bacterial Microarray Group at St George's and acted as User Group Co-ordinator for both the C. jejuni and H. pylori microarrays produced by the BμG@S group.

Nick has had a long involvement with the Microbiology Society (previously known as the Society of General Microbiology) (https://www.microbiologysociety.org). Nick stood down as Chair of the Prokaryotic Division in September 2013 after the 2 year term of office. Previously Nick was Chair Elect of the Prokaryotic Division (2009-2011), a member of the Prokaryotic Division (2008-2009) and Convener of the Microbial Infection Group (2005-2008), having served as a committee member of the Microbial Infection Group since 2001. He was also a member (2001-2007) of the Steering Committee of ARK Genomics (http://www.ark-genomics.org) based at the Roslin Institute (Edinburgh).

Research Area

Bacteria

Disease control

Molecular biology

Disease and Health Conditions

Infectious diseases

Diarrhoeal diseases

Country

United Kingdom

Ireland

Region

European Union

Selected Publications

Sodium Taurocholate Stimulates Campylobacter jejuni Outer Membrane Vesicle Production via Down-Regulation of the Maintenance of Lipid Asymmetry Pathway.

DAVIES, C; Taylor, AJ; ELMI, A; Winter, J; LIAW, J; GRABOWSKA, AD; GUNDOGDU, O; WREN, BW; Kelly, DJ; DORRELL, N;

2019

Frontiers in Cellular and Infection Microbiology

Comprehensive Longitudinal Microbiome Analysis of the Chicken Cecum Reveals a Shift From Competitive to Environmental Drivers and a Window of Opportunity for Campylobacter.

Ijaz, UZ; SIVALOGANATHAN, L; McKenna, A; Richmond, A; Kelly, C; Linton, M; Stratakos, AC; Lavery, U; ELMI, A; WREN, BW; DORRELL, N; Corcionivoschi, N; GUNDOGDU, O;

2018

Frontiers in microbiology

The bile salt sodium taurocholate induces Campylobacter jejuni outer membrane vesicle production and increases OMV-associated proteolytic activity.

ELMI, A; Dorey, A; Watson, E; Jagatia, H; Inglis, NF; GUNDOGDU, O; Bajaj-Elliott, M; WREN, BW; Smith, DG E; DORRELL, N;

2017

Cellular microbiology

The In Vitro and In Vivo Effect of Carvacrol in Preventing Campylobacter Infection, Colonization and in Improving Productivity of Chicken Broilers.

Kelly, C; GUNDOGDU, O; Pircalabioru, G; Cean, A; Scates, P; Linton, M; Pinkerton, L; Magowan, E; Stef, L; Simiz, E; Pet, I; Stewart, S; STABLER, R; WREN, B; DORRELL, N; Corcionivoschi, N;

2017

Foodborne pathogens and disease

The Campylobacter jejuni Oxidative Stress Regulator RrpB Is Associated with a Genomic Hypervariable Region and Altered Oxidative Stress Resistance.

GUNDOGDU, O; Da Silva, DT; Mohammad, B; ELMI, A; WREN, BW; Van Vliet, AH M; DORRELL, N;

2016

Frontiers in microbiology

Pathogenicity and virulence of <i>Campylobacter jejuni</i>: What do we really know?

Omole, Z; Dorrell, N; Elmi, A; Nasher, F; GUNDOGDU, O; WREN, BW;

2024

Virulence

Campylobacter jejuni Modulates Reactive Oxygen Species Production and NADPH Oxidase 1 Expression in Human Intestinal Epithelial Cells

HONG, G; DAVIES, C; Omole, Z; Liaw, J; Grabowska, AD; Canonico, B; Corcionivoschi, N; WREN, BW; DORRELL, N; ELMI, A; GUNDOGDU, O;