Integrative metabolomic and transcriptomic analysis reveals host-parasite dynamics in falciparum malaria
Looking at mechanisms of host–parasite interactions in vivo in malaria
Unveiling the mechanisms of host–parasite interactions in vivo in malaria can lead to the development of antimalarial strategies adapted to physiologically relevant contexts. We implemented a strategy that combines prospective population sampling and multi-omics profiling of host-parasite responses with a focus on studying transcriptomes, metabolomes and lipidomes of children sampled before and during the blood-stage infection across three ethnic groups in Burkina Faso. This strategy provided a high-resolution depiction of metabolic perturbations induced in vivo by P. falciparum and revealed clinically relevant molecular nuances and host-parasite interactions within the human host.
Speaker
Youssef Idaghdour is a Global Network Associate Professor of Biology and Co-Director of the Public Health Research Center at New York University Abu Dhabi. Dr. Idaghdour received a Ph.D. in Genetics at North Carolina State University under a Fulbright Fellowship and was a Banting Postdoctoral Fellow at Sainte-Justine Research Center in Montreal prior to joining NYU Abu Dhabi, where he established a research programme on population and medical genomics of complex traits with a focus on the host immune response to infection, immunometabolism and host-parasite interactions in malaria using multi-omics approaches.
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