Below is a selection of highlighted research projects and papers related to the AMR Centre.
Treatment of multi-drug-resistant Acinetobacter baumannii and Klebsiella pneumonia infections using bacteriophage capsule depolymerases
LSHTM staff: Richard Stabler, Nick Thomson
Funding: MRC
Collaborators: UCL
Project duration: 2016 - 2019
Estimating the costs in five countries of the diagnosis and treatment of multi-drug resitance TB (VALUE-TB)
LSHTM staff: Anna Vassall, Sedona Sweeney, Yoko Laurence
Funding: Bill & Melinda Gates Foundation
Collaborators: WHO, KEMRI-Wellcome Trust, Armauer Hansen Research Institute, George Institute
Project duration: 2017 - 2019
Anti-Microbials In Society (AMIS): a Global Interdisciplinary Research Hub
LSHTM staff: Clare Chandler, Coll Hutchison, Laurie Denyer Willis, Sarah Staedke, Bianca D'Souza
Funding: ESRC
Collaborators: Ministry of Public Health, Thailand; Mahidol University, Thailand; Infectious Diseases Research Collaboration, Uganda
Project duration: 2017 - 2021
Sources, seasonality, transmission and control: Campylobacter & human behaviour in a changing environment
LSHTM staff: Brendan Wren
Funding: MRC
Project duration: -
Antibiotic Prescribing and Resistance: Views from LMIC Prescribing and Dispensing Professionals
LSHTM staff: Clare Chandler, Maddy Pearson, Jiolijn Hendricks, Sarah Smith
Funding: WHO
Project duration: 2017 - 2018
Personalised Risk assessment in febrile illness to optimise Real-life Management across the European Union (PERFORM)
LSHTM staff: Shunmay Yeung, Martin Hibberd, Alec Miners
Funding: European Commission (Horizon 2020)
Collaborators: Imperial College
Project duration: 2016 - 2020
Multi-drug resistance in malaria under combination therapy: assessment of specific markers and development of innovative, rapid and simple diagnostics 9 (MALACTRES)
LSHTM staff: Colin Sutherland, Rachel Hallett, Brighid O'Neill, Teun Bousema
Collaborators: KCMC
Project duration: -
Modeling vaccines and AMR
LSHTM staff: Mark Jit, Nick Davies, Katherine Atkins
Funding: NIHR
Project duration: 2014 - 2019
A randomised experiment exploring antibiotic prescribing practices among private health facilities in Tanzania
This study, embedded in a wider evaluation of quality of care in private health facilities in Tanzania, aims to identify the role of patient knowledge and provider driven demand in overprescription of antibiotics.
Tackling the irrational use of antibiotics in outpatient settings is seen as a cornerstone of the global fight against AMR, but the drivers of unnecessary antibiotic prescriptions are still poorly understood, particularly in low- and middle-income countries. This study, embedded in a wider evaluation of quality of care in private health facilities in Tanzania, aims to identify the role of patient knowledge and provider driven demand in overprescription of antibiotics. A standardised patient, or mystery shopper, presented to each participating health facility with symptoms of an uncomplicated upper respiratory tract infection which did not merit antibiotics. Facilities were randomised to receive the standard case, or a patient who additionally demonstrated knowledge of correct prescription practices. All drugs prescribed and patient expenditure were recorded. An earlier facility survey allows further exploration of the role of health provider payment and incentives in prescription practices.
LSHTM staff: Catherine Goodman, Tim Powell-Jackson, Jessica King
Funding: HRSI
Project duration: 2016 - 2019
Low-cost, non-commercial drug susceptibility testing of mycobacterium tuberculosis
LSHTM staff: David Moore, Jackie Cliff, Claire Broderick, Kate Gaskell
Funding: Wellcome Trust, MRC Newton Fund, Bill & Melinda Gates Foundation