Exploring the effect of using smaller Pneumococcal conjugate vaccines doses (fractional doses) or the effect of reducing the number of doses (dose-sparing schedules) on immune responses.
Pneumococcal conjugate vaccines (PCVs) are highly effective at preventing meningitis, sepsis and pneumonia caused by pneumococcal bacteria.
However, the available vaccines are expensive. Speakers from LSHTM and Epicentre - Médecins Sans Frontières (MSF), will present results from three different studies that explore the effect of using smaller doses (fractional doses) or the effect of reducing the number of doses (dose-sparing schedules) on immune responses, carriage and/or disease. A discussion and Q&A will be held at the end of the presentations.
Live translation into French and Spanish will be provided.
Speakers
Katherine Gallagher, Associate Professor of Epidemiology at London School of Hygiene and Tropical Medicine
Kate is an epidemiologist with training in infectious disease epidemiology and vaccine research. Kate has lived in Kenya since 2018 and works as a visiting scientist at KEMRI-Wellcome Trust Research Programme. She will present the results of a large individually randomized non-inferiority trial of the immunogenicity of fractional doses of pneumococcal conjugate vaccine in Kenyan infants, funded by the Bill and Melinda Gates Foundation.
Matthew Coldiron, Medical Epidemiologist at Epicentre - Médecins Sans Frontières (MSF) / Doctors Without Borders
Matthew is a medical doctor with 10 years’ experience in epidemiological research, especially the design and management of clinical trials. Matthew will present the results of a large cluster randomized controlled trial of the effect of a mass campaign with fractional doses of PCV10 on population level carriage in Niger.
Kevin van Zandvoort, Research Fellow in Epidemiology at London School of Hygiene and Tropical Medicine
Kevin works in epidemiology and mathematical modelling of infectious disease at the London School of Hygiene & Tropical Medicine. His research focusses on identifying optimal pneumococcal vaccine strategies for populations affected by crises. He will present the results of mathematical models that predict the impact of reducing 3-dose schedules to 2-dose schedules using trial data from low-income settings.
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