Below is a selection of highlighted research projects and papers related to the AMR Centre.
Use of transposon-directed insertion site sequencing to identify new essential drug targets
LSHTM staff: Sam Willcocks
Funding: UK Defence Science and Technology Laboratory
Working with plantation owners to control malaria and antimalarial drug resistance
LSHTM staff: Shunmay Yeung
Funding: Bill and Melinda Gates Foundation
Project duration: 2014-2015
Application of phylogenetic statistical & computational approaches to unravel genotype – phenotype
Working in the application of genome-wide association studies (GWAS) in bacteria to identify the genes that make bacteria resistant to antibiotics and able to cause infections.
LSHTM staff: Sharon Peacock, Francesc Coll
Funding: Wellcome Trust
Collaborators: Julian Parkhill (Wellcome Trust Sanger Institute), Joan Geoghegan (Trinity College Dublin), National Carbapenemase Producing Enterobacteriaceae Reference Laboratory, Ireland
Project Duration: 2016 – 2020
Translating whole genome sequence technology into diagnostic and public health microbiology
I am currently working in the application of whole-genome sequencing to outbreak investigation and antimicrobial prescribing in Staphylococcus aureus. Integrating whole genome sequencing into health services for surveillance of Carbapenem resistant Enterobacteriaceae in Ireland.
Project Duration: 2014 – 2020
LSHTM lead investigator: Sharon Peacock
LSHTM staff: Catherine Ludden, Francesc Coll
Funding: Health Innovation Challenge Fund
Collaborators: Julian Parkhill (Wellcome Trust Sanger Institute), Paul Rhodes (Next Gen Diagnostics), Martin Cormican (Natioal Univerity of Ireland Galway and National Carbapenemase Producing Enterobacteriaceae Reference Laboratory Ireland)
Location: UK